How Does Tobacco Cause Cancer?
September 29, 2023 | by Yashaswi Pathakamuri | Posted in FAQ's
Tobacco is a major risk factor for several types of cancer, including lung, mouth, throat, esophagus, pancreas, bladder, kidney, and more. The link between tobacco use and cancer is well-established, and there are several mechanisms through which tobacco can cause cancer:
- Carcinogenic Compounds: Tobacco smoke contains thousands of chemicals, many of which are known carcinogens (cancer-causing substances). These include chemicals like benzene, formaldehyde, nitrosamines, and polycyclic aromatic hydrocarbons (PAHs). When these chemicals are inhaled or come into contact with the cells lining the respiratory and digestive tracts, they can damage the DNA within those cells, leading to mutations that can initiate cancerous growth.
- Direct Irritation: The heat and irritants in tobacco smoke can directly damage the cells in the tissues they come into contact with. This irritation can lead to inflammation, chronic tissue damage, and eventually cancerous changes in the affected tissues.
- Metabolic Effects: Tobacco smoke can disrupt normal metabolic processes in the body, leading to changes in hormone levels and the immune system. These disruptions can create an environment conducive to cancer development and progression.
- Formation of DNA Adducts: Some chemicals in tobacco smoke can form DNA adducts, which are molecules that bind to DNA and cause structural damage. These adducts can interfere with DNA repair mechanisms and increase the likelihood of DNA mutations, which can lead to cancer.
- Promotion of Angiogenesis: Tobacco use can promote the formation of new blood vessels, a process known as angiogenesis. This is essential for tumors to grow and spread, as they require a blood supply to provide oxygen and nutrients. Tobacco-related compounds can stimulate angiogenesis, facilitating tumor growth.
- Weakening of Immune Responses: Tobacco use can weaken the immune system’s ability to identify and destroy cancer cells, allowing them to evade the body’s natural defenses and proliferate.
It’s important to note that not only smoking tobacco but also other forms of tobacco use, such as chewing tobacco and snuff, can increase the risk of cancer. Furthermore, secondhand smoke, which is the smoke exhaled by a smoker or released from the burning end of a cigarette, can also expose non-smokers to carcinogenic substances and increase their cancer risk.
Quitting tobacco use is one of the most effective ways to reduce the risk of cancer and improve overall health. If you use tobacco and are concerned about your cancer risk or need help quitting, consider seeking support from healthcare professionals or smoking cessation programs, which can provide guidance and resources to help you quit successfully.
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