Can Methotrexate Cause Diabetes?
July 20, 2024 | by Yashaswi Pathakamuri | Posted in FAQ's
Methotrexate is a medication commonly used to treat certain types of cancer and autoimmune diseases, such as rheumatoid arthritis and psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for cell replication. While methotrexate has a range of side effects, causing diabetes is not typically one of them.
However, there are a few important considerations:
- Indirect Effects: Methotrexate can cause liver damage in some patients, which can indirectly affect blood sugar levels. Liver dysfunction can impair glucose metabolism and potentially contribute to insulin resistance over time.
- Associated Conditions: Individuals taking methotrexate for autoimmune conditions like rheumatoid arthritis may already have an increased risk of developing diabetes due to the chronic inflammation associated with these diseases.
- Corticosteroid Use: Patients with autoimmune diseases often take corticosteroids (such as prednisone) in addition to methotrexate. Long-term use of corticosteroids is known to increase the risk of developing diabetes.
If you are taking methotrexate and are concerned about your risk of diabetes, it’s important to discuss this with your healthcare provider. They can monitor your blood sugar levels and provide guidance on managing any potential risks.