Why Does Amlodipine Cause Leg Swelling?

April 3, 2024 | by Yashaswi Pathakamuri | Posted in FAQ's

Leg Swelling

Amlodipine is a medication commonly used to treat high blood pressure (hypertension) and certain types of chest pain (angina). Leg swelling, also known as peripheral edema, is a known side effect of amlodipine. Several mechanisms may contribute to this side effect:

  • Peripheral vasodilation: Amlodipine belongs to a class of medications called calcium channel blockers. It works by relaxing and widening the blood vessels, which helps to lower blood pressure. However, this vasodilating effect can sometimes lead to fluid retention in the tissues, particularly in the lower extremities, resulting in leg swelling.
  • Venous pooling: Amlodipine can affect the balance of fluid in the body by dilating blood vessels, which may lead to increased pooling of blood in the veins. This pooling can cause fluid to leak out of the blood vessels and accumulate in the surrounding tissues, contributing to swelling in the legs.
  • Sodium and water retention: Although less common, some individuals may experience sodium and water retention as a side effect of amlodipine. This retention of sodium and water can exacerbate fluid accumulation in the tissues, leading to leg swelling.
  • Individual susceptibility: Not everyone who takes amlodipine will experience leg swelling. Some individuals may be more susceptible to this side effect due to factors such as age, pre-existing conditions (such as heart failure or kidney disease), or concurrent use of other medications that affect fluid balance.

It’s essential for individuals taking amlodipine to be aware of the potential side effects, including leg swelling, and to promptly report any unusual swelling or symptoms to their healthcare provider. In some cases, adjusting the dosage or switching to an alternative medication may be necessary to manage this side effect effectively.

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